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Pericardial malignant infiltration as the cause of sudden death of a patient with metastatic urothelial carcinoma treated with atezolizumab.
Palacka, Patrik; Janega, Pavol; Polakova, Hana; Slopovsky, Jan; De Angelis, Valentina; Mego, Michal.
Afiliação
  • Palacka P; 2nd Department of Oncology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia. pal_patrick@yahoo.co.uk.
  • Janega P; National Cancer Institute, Klenova 1, 833 10, Bratislava, Slovakia. pal_patrick@yahoo.co.uk.
  • Polakova H; Department of Pathology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.
  • Slopovsky J; Department of Radiology, National Cancer Institute, Bratislava, Slovakia.
  • De Angelis V; 2nd Department of Oncology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.
  • Mego M; National Cancer Institute, Klenova 1, 833 10, Bratislava, Slovakia.
BMC Urol ; 22(1): 108, 2022 Jul 18.
Article em En | MEDLINE | ID: mdl-35850756
BACKGROUND: Muscle-infiltrating urothelial carcinoma of the bladder is the most common genitourinary cancer. Immunotherapeutic agents targeting protein-1 programmed death or protein-1 programmed death ligand are currently considered the standard treatment in patients with either inoperable locally advanced or metastatic urothelial carcinoma (MUC) after platinum-based chemotherapy failure. CASE PRESENTATION: Here we report the case of a Caucasian male patient with metastatic urothelial carcinoma treated with second-line atezolizumab within a trial who achieved complete response by computed tomography (CT), but suddenly died due to cardiac tamponade resulting from malignant pericardial infiltration. Histopathology confirmed this as the only site of disease progression. CONCLUSIONS: Cardiovascular toxicity of atezolizumab was considered within differential diagnoses, however histopathological examination revealed progression of malignancy in the pericardium as the cause of the sudden death. This is the first published case report of a patient treated with second-line atezolizumab in whom the rare disease progression of pericardial infiltration was confirmed. Despite its rarity, the clinicians should always consider the possibility of pericardial metastases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Carcinoma de Células de Transição / Neoplasias Urológicas Limite: Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Carcinoma de Células de Transição / Neoplasias Urológicas Limite: Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article