Anesthesia promotes acute expression of genes related to Alzheimer's disease and latent tau aggregation in transgenic mouse models of tauopathy.

Eun, John David; Jimenez, Heidy; Adrien, Leslie; Wolin, Adam; Marambaud, Philippe; Davies, Peter; Koppel, Jeremy L

Eun, John David; Jimenez, Heidy; Adrien, Leslie; Wolin, Adam; Marambaud, Philippe; Davies, Peter; Koppel, Jeremy L.

Afiliação

Eun JD; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Jimenez H; Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institutes for Medical Research, 350 Community Drive, 4th floor, Manhasset, NY, 11030, USA.
Adrien L; Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institutes for Medical Research, 350 Community Drive, 4th floor, Manhasset, NY, 11030, USA.
Wolin A; Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institutes for Medical Research, 350 Community Drive, 4th floor, Manhasset, NY, 11030, USA.
Marambaud P; Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institutes for Medical Research, 350 Community Drive, 4th floor, Manhasset, NY, 11030, USA.
Davies P; Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institutes for Medical Research, 350 Community Drive, 4th floor, Manhasset, NY, 11030, USA.
Koppel JL; Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institutes for Medical Research, 350 Community Drive, 4th floor, Manhasset, NY, 11030, USA.

Mol Med ; 28(1): 83, 2022 07 20.

Article em En | MEDLINE | ID: mdl-35858831

Assuntos

Doença de Alzheimer; Anestesia; Tauopatias; Idoso; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Anestesia/efeitos adversos; Animais; Modelos Animais de Doenças; Humanos; Mamíferos/metabolismo; Glicoproteínas de Membrana/metabolismo; Camundongos; Camundongos Transgênicos; Fosforilação; Receptores Imunológicos; Tauopatias/genética; Tauopatias/metabolismo; Tauopatias/patologia; Proteínas tau/genética; Proteínas tau/metabolismo

Palavras-chave

Alzheimer's disease; Anesthesia; Hibernation; Hyperphosphorylation; Hypothermia; Isoflurane; Neuroinflammation; Tau

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tauopatias / Doença de Alzheimer / Anestesia Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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