Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11.

Harberts, Erin M; Grubaugh, Daniel; Akuma, Daniel C; Shin, Sunny; Ernst, Robert K; Brodsky, Igor E

Harberts, Erin M; Grubaugh, Daniel; Akuma, Daniel C; Shin, Sunny; Ernst, Robert K; Brodsky, Igor E.

Afiliação

Harberts EM; Department of Microbial Pathogenesis, University of Maryland, School of Dentistry, Baltimore, Maryland, USA.
Grubaugh D; Department of Pathobiology, University of Pennsylvaniagrid.25879.31 School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.
Akuma DC; Department of Pathobiology, University of Pennsylvaniagrid.25879.31 School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.
Shin S; Department of Microbiology, University of Pennsylvaniagrid.25879.31 Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ernst RK; Department of Microbial Pathogenesis, University of Maryland, School of Dentistry, Baltimore, Maryland, USA.
Brodsky IE; Department of Pathobiology, University of Pennsylvaniagrid.25879.31 School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.

Infect Immun ; 90(8): e0020122, 2022 08 18.

Article em En | MEDLINE | ID: mdl-35862717

Assuntos

Lipídeo A; Receptor 4 Toll-Like; Acilação; Animais; Caspases; Lipídeo A/química; Lipopolissacarídeos; Camundongos; Receptor 4 Toll-Like/metabolismo

Palavras-chave

LPS; TLR4; caspase-11; inflammasome; lipid A; pyroptosis; sepsis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 4 Toll-Like / Lipídeo A Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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