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Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11.
Zhang, Long; Hobeika, Charbel S; Khabibullin, Damir; Yu, Deyang; Filippakis, Harilaos; Alchoueiry, Michel; Tang, Yan; Lam, Hilaire C; Tsvetkov, Peter; Georgiou, George; Lamb, Candice; Stone, Everett; Puigserver, Pere; Priolo, Carmen; Henske, Elizabeth P.
Afiliação
  • Zhang L; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Hobeika CS; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Khabibullin D; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Yu D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.
  • Filippakis H; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Alchoueiry M; Broad Institute of MIT and Harvard, Cambridge, MA 02139.
  • Tang Y; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Lam HC; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Tsvetkov P; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Georgiou G; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Lamb C; Broad Institute of MIT and Harvard, Cambridge, MA 02139.
  • Stone E; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.
  • Puigserver P; Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712.
  • Priolo C; Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712.
  • Henske EP; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.
Proc Natl Acad Sci U S A ; 119(28): e2122840119, 2022 07 12.
Article em En | MEDLINE | ID: mdl-35867762
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Cistina / Sistema y/ de Transporte de Aminoácidos / Ferroptose / Glutationa / Neoplasias Renais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Cistina / Sistema y/ de Transporte de Aminoácidos / Ferroptose / Glutationa / Neoplasias Renais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article