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Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α.
Tawa, Paul; Zhang, Lei; Metwally, Essam; Hou, Yan; McCoy, Mark A; Seganish, W Michael; Zhang, Rumin; Frank, Emily; Sheth, Payal; Hanisak, Jennifer; Sondey, Christopher; Bauman, David; Soriano, Aileen.
Afiliação
  • Tawa P; Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Zhang L; Biologics AR&D Immunoassay Group, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Metwally E; Computational & Structural Chemistry, Merck & Co, Inc, South San Francisco, California, USA.
  • Hou Y; Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • McCoy MA; Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Seganish WM; Discovery Chemistry, Merck & Co, Inc, South San Francisco, California, USA.
  • Zhang R; Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Frank E; Quantitative Biosciences, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Sheth P; Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Hanisak J; Discovery Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Sondey C; Quantitative Biosciences, Merck & Co, Inc, Boston, Massachusetts, USA.
  • Bauman D; Discovery Biology, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Soriano A; Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA. Electronic address: aileen.soriano@merck.com.
J Biol Chem ; 298(9): 102284, 2022 09.
Article em En | MEDLINE | ID: mdl-35868561
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Doenças Cardiovasculares / GMP Cíclico / Proteína Quinase Dependente de GMP Cíclico Tipo I Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Doenças Cardiovasculares / GMP Cíclico / Proteína Quinase Dependente de GMP Cíclico Tipo I Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article