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Etiology and Secular Trends in Primary Amenorrhea in 856 Patients: A 17-Year Retrospective Multicenter Study in Korea.
Kim, Hoon; Lee, Mee-Hwa; Lee, Dong-Yun; Kim, Hyein; Lee, Hyun Jung; Kim, Miran; Park, Joo Hyun; Yun, Bo Hyon; Lee, Sa Ra; Cho, Hyun Hee; Kang, Byung Moon.
Afiliação
  • Kim H; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
  • Lee MH; Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea.
  • Lee DY; Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • Kim H; Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dongyun0406.lee@samsung.com.
  • Lee HJ; Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea.
  • Kim M; Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • Park JH; Department of Obstetrics and Gynecology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
  • Yun BH; Department of Obstetrics and Gynecology, Yongin Severance Hospital, Yonsei University Medical College, Yongin, Korea.
  • Lee SR; Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Cho HH; Department of Obstetrics and Gynecology, Seoul Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Kang BM; Department of Obstetrics and Gynecology, Eunpyung St. Mary's Hospital, Catholic University Medical College, Seoul, Korea.
J Korean Med Sci ; 37(29): e230, 2022 Jul 25.
Article em En | MEDLINE | ID: mdl-35880506
BACKGROUND: This study was performed to evaluate etiologies and secular trends in primary amenorrhea in South Korea. METHODS: This retrospective multi-center study analyzed 856 women who were diagnosed with primary amenorrhea between 2000 and 2016. Clinical characteristics were compared according to categories of amenorrhea (hypergonadotropic/hypogonadotropic hypogonadism, eugonadism, disorders of sex development) or specific causes of primary amenorrhea. In addition, we assessed secular trends of etiology and developmental status based on the year of diagnosis. RESULTS: The most frequent etiology was eugonadism (39.8%). Among specific causes, Müllerian agenesis was most common (26.2%), followed by gonadal dysgenesis (22.4%). Women with hypergonadotropic hypogonadism were more likely to have lower height and weight, compared to other categories. In addition, the proportion of cases with iatrogenic or unknown causes increased significantly in hypergonadotropic hypogonadism category, but overall, no significant secular trends were detected according to etiology. The proportion of anovulation including polycystic ovarian syndrome increased with time, but the change did not reach statistical significance. CONCLUSION: The results of this study provide useful clinical insight on the etiology and secular trends of primary amenorrhea. Further large-scale, prospective studies are necessary.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos 46, XX do Desenvolvimento Sexual / Hipogonadismo Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos 46, XX do Desenvolvimento Sexual / Hipogonadismo Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article