A Comprehensive Study to Identify Major Metabolites of an Amoxicillin-Sulbactam Hybrid Molecule in Rats and Its Metabolic Pathway Using UPLC-Q-TOF-MS/MS.

Zhao, Fei-Ke; Shi, Ren-Bin; Sun, Yu-Bin; Yang, Shuang-Yun; Chen, Liang-Zhu; Fang, Bing-Hu

Zhao, Fei-Ke; Shi, Ren-Bin; Sun, Yu-Bin; Yang, Shuang-Yun; Chen, Liang-Zhu; Fang, Bing-Hu.

Afiliação

Zhao FK; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, China.
Shi RB; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, China.
Sun YB; Shenzhen Institute for Drug Control, Shenzhen 518057, China.
Yang SY; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, China.
Chen LZ; Guangdong Dahuanong Animal Health Products Co., Ltd., Yunfu 527400, China.
Fang BH; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510630, China.

Metabolites ; 12(7)2022 Jul 18.

Article em En | MEDLINE | ID: mdl-35888786

Palavras-chave

amoxicillin; drug metabolism; hybrid molecule; sulbactam; ultrahigh performance liquid chromatographyquadrupole time-of-flight tandem mass spectrometry

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2022 Tipo de documento: Article