[Association of gene polymorphisms DRD3 rs6280, COMT rs4680 and HTR2A rs7322347 with schizophrenia]. / Assotsiatsiya geneticheskikh polimorfizmov rs6280 gena DRD3, rs4680 gena COMT, rs7322347 gena HTR2A s shizofreniei.
Zh Nevrol Psikhiatr Im S S Korsakova
; 122(7): 115-120, 2022.
Article
em Ru
| MEDLINE
| ID: mdl-35904302
ABSTRACT
OBJECTIVE:
To check the association of genetic polymorphisms rs6280 of the DRD3 gene, rs4680 of the COMT gene, rs7322347 of the HTR2A gene with schizophrenia. MATERIAL ANDMETHODS:
The sample included 300 inpatients with paranoid schizophrenia. Inclusion criteria age 18-50 years, established diagnosis «Schizophrenia, paranoid form¼, duration of psychiatric disorders not less than 5 years. The healthy control group consisted of 290 subjects. The association between polymorphisms and the study groups was assessed by logistic regression.RESULTS:
The CC genotype of the rs6280 polymorphism is associated with schizophrenia (OR 3.37 (1.50; 8.03)). The TT genotype of the rs7322347 polymorphism is associated with controls (OR 1.83 (1.25; 2.68)).CONCLUSION:
These analyses confirmed the hypothesis that the genetic polymorphisms rs7322347 of the HTR2A gene (p=0.006) and rs6280 of the DRD3 gene (p=0.004) were associated with the disease. The hypothesis of an association of the rs4680 polymorphism of the COMT gene could not be confirmed.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Catecol O-Metiltransferase
/
Receptor 5-HT2A de Serotonina
/
Receptores de Dopamina D3
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
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Adult
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Humans
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Middle aged
Idioma:
Ru
Ano de publicação:
2022
Tipo de documento:
Article