The generation of a lactate-rich environment stimulates cell cycle progression and modulates gene expression on neonatal and hiPSC-derived cardiomyocytes.

Ordoño, Jesús; Pérez-Amodio, Soledad; Ball, Kristen; Aguirre, Aitor; Engel, Elisabeth

Ordoño, Jesús; Pérez-Amodio, Soledad; Ball, Kristen; Aguirre, Aitor; Engel, Elisabeth.

Afiliação

Ordoño J; Biomaterials for Regenerative Therapies Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology, Barcelona, Spain; CIBER Bioengineering, Biomaterials and Nanotechnology, Spain.
Pérez-Amodio S; Biomaterials for Regenerative Therapies Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology, Barcelona, Spain; CIBER Bioengineering, Biomaterials and Nanotechnology, Spain; IMEM-BRT Group, Dpt. Material Science and Engineering, Universitat Politecni
Ball K; Regenerative Biology and cell Reprogramming Laboratory, Institute for Quantitative Health Sciences and Engineering (IQ), Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, Michigan State University, MI, USA.
Aguirre A; Regenerative Biology and cell Reprogramming Laboratory, Institute for Quantitative Health Sciences and Engineering (IQ), Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, Michigan State University, MI, USA.
Engel E; Biomaterials for Regenerative Therapies Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology, Barcelona, Spain; CIBER Bioengineering, Biomaterials and Nanotechnology, Spain; IMEM-BRT Group, Dpt. Material Science and Engineering, Universitat Politecni

Biomater Adv ; 139: 213035, 2022 Aug.

Article em En | MEDLINE | ID: mdl-35907761

Assuntos

Células-Tronco Pluripotentes Induzidas; Miócitos Cardíacos; Animais; Proteínas Morfogenéticas Ósseas/metabolismo; Ciclo Celular/genética; Ciclo Celular/fisiologia; Diferenciação Celular/genética; Diferenciação Celular/fisiologia; Expressão Gênica; Humanos; Células-Tronco Pluripotentes Induzidas/metabolismo; Ácido Láctico/metabolismo; Camundongos; Miócitos Cardíacos/metabolismo

Palavras-chave

Cardiac tissue engineering; Cardiomyocytes; Cell cycle; Induced pluripotent stem cells; Lactate; Metabolic environment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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