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Hand-foot syndrome caused by capecitabine: incidence, risk factors and the role of dermatological evaluation.
de Queiroz, Marina Vieira Rodrigues; de Medeiros, Ana Carolina Tardin Rodrigues; Toledo, Sarah Pires; de Abreu Sarmenghi, Karina Demoner; de Vasconcellos, Vitor Fiorin.
Afiliação
  • de Queiroz MVR; Department of Dermatology, Santa Casa de Misericórdia de Vitória Hospital, Vitória, ES, 29025-023, Brazil.
  • de Medeiros ACTR; 0000-0001-5544-458X.
  • Toledo SP; Department of Dermatology, Santa Casa de Misericórdia de Vitória Hospital, Vitória, ES, 29025-023, Brazil.
  • de Abreu Sarmenghi KD; 0000-0002-6492-3811.
  • de Vasconcellos VF; Department of Dermatology, Santa Casa de Misericórdia de Vitória Hospital, Vitória, ES, 29025-023, Brazil.
Ecancermedicalscience ; 16: 1390, 2022.
Article em En | MEDLINE | ID: mdl-35919225
Hand-foot syndrome (HFS), or palmar-plantar erythrodysesthesia, is characterised by erythema, oedema and dysesthesia, which can progress to blistering and ulceration. This condition is described as a common adverse effect of the chemotherapeutic agent capecitabine. The study set out to evaluate real-world incidences; assess severity based on clinical criteria, such as local symptoms, dyschromia, erythema, oedema and ulcerations; and associated factors, such as type of solid tumour, chemotherapy regimen, number of cycles, sex, age and Eastern Cooperative Oncology Group Performance Scale of HFS, related to the use of capecitabine. This is a single-centre prospective cohort study carried out jointly by the departments of clinical oncology and dermatology of a university hospital in the southeast of Brazil. The study showed a 34% incidence of HFS, with most cases classified as mild. There was statistical significance in the correlation of the syndrome with sex and performance scores. HFS is the most common and limiting adverse reaction to capecitabine, and causes significant functional and quality impairments in patients with cancer. With this study, we have reinforced the importance of multidisciplinary assessment for early diagnosis and adequate follow-up.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article