Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysis.

Ibrahim, Ibrahim M; Elfiky, Abdo A; Fathy, Mohamed M; Mahmoud, Sara H; ElHefnawi, Mahmoud

Ibrahim, Ibrahim M; Elfiky, Abdo A; Fathy, Mohamed M; Mahmoud, Sara H; ElHefnawi, Mahmoud.

Afiliação

Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Elfiky AA; Biophysics Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Fathy MM; Biophysics Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Mahmoud SH; Centre of Scientific Excellence for Influenza Viruses (CSEIV), National Research Centre, Cairo, 12622, Egypt.
ElHefnawi M; Biomedical Informatics and Chemoinformatics Group (BICG), Informatics and Systems Department, National Research Centre, Cairo, 12622, Egypt. mahef@aucegypt.edu.

Sci Rep ; 12(1): 13337, 2022 08 03.

Article em En | MEDLINE | ID: mdl-35922447

Assuntos

Tratamento Farmacológico da COVID-19; SARS-CoV-2; Antivirais/química; Antivirais/farmacologia; Endorribonucleases/metabolismo; Humanos; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Proteínas não Estruturais Virais/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Tipo de estudo: Diagnostic_studies / Guideline / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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