In vitro antiviral effect of Mexican and Brazilian propolis and phenolic compounds against human coronavirus 229E.
Int J Environ Health Res
; 33(12): 1591-1603, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-35951754
ABSTRACT
Propolis is a resinous substance collected by bees (Apis mellifera). It is used for its biological properties. This natural product is available as a safe therapeutic option. Herein, we report the antiviral effects of brown propolis extract from Mexico and green and red propolis extracts from Brazil, as well as their phenolic compounds (quercetin, caffeic acid, and rutin) in preventing infection of MRC-5 cells by HCoV-229E. Normal human fibroblast lung cells (MRC-5) were used to determine the cytotoxicity of the compounds. All samples studied showed antiviral activity. Green and brown propolis extracts, and quercetin exhibited the best EC50 values with values of 19.080, 11.240, and 77.208 µg/mL against HCoV-229E, respectively, and with TC50 of 62.19, 29.192, and 298 µg/mL on MRC-5 cells, respectively. These results are the first in vitro study of the effects of propolis on HCoV-229E and provide the basis for the development of natural formulations against other coronavirus strains.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Própole
/
Coronavirus Humano 229E
Limite:
Animals
/
Humans
País/Região como assunto:
America do sul
/
Brasil
/
Mexico
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article