Adsorption and leaching of ß-blockers in fluvo-aquic and black soil: Behavior characteristic and enantiomer selectivity.

ABSTRACT

ß-blockers are widely used chiral pharmaceuticals to treat hypertension and cardiovascular diseases, which are ubiquitously detected in the water-soil environment. However, little is known about their biogeochemical behaviors and enantiomer selectivity during soil migration and transformation. In this study, the adsorption and leaching behaviors of ß-blockers in fluvo-aquic soil and black soil were investigated. The adsorption of ß-blockers was fit well by the Freundlich adsorption isotherm (R2 > 0.913) and the adsorption affinity of ß-blockers decreased in the following order propranolol (logarithm of Freundlich adsorption coefficient log Kf = 1.46-2.55) > atenolol (log Kf = 0.53-1.04) > sotalol (log Kf = 0.32-1.01). An increase in ionic strength and dissolved organic matter (DOM) inhibited their soil adsorption. Ionic change is the main driving force for adsorption. Besides, hydrophobic partitioning and hydrogen bonding played key roles in the adsorption of propranolol and atenolol, respectively. The leaching behaviors of ß-blockers are related to their hydrophobicity. An increase in ionic strength enhanced the migration of ß-blockers to deeper soil layers, and the presence of DOM accelerated the migration of sotalol and propranolol. The migration potential of ß-blockers in black soil is lower than that in fluvo-aquic soil, which could be ascribed to the higher organic matter content and strong ion exchange ability of black soil. Further, more significant enantiomer selectivity of ß-blockers was found in black soil (e.g. enantiomer fraction of atenolol = 0.61) than in fluvo-aquic soil (e.g. enantiomer fraction of atenolol = 0.53) during the leaching process. The microbial activity might influence the enantiomer selectivity of studied ß-blockers during soil leaching.