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A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs.
Bogaert, Bram; Sauvage, Félix; Guagliardo, Roberta; Muntean, Cristina; Nguyen, Van Phuc; Pottie, Eline; Wels, Mike; Minnaert, An-Katrien; De Rycke, Riet; Yang, Qiangbing; Peer, Dan; Sanders, Niek; Remaut, Katrien; Paulus, Yannis M; Stove, Christophe; De Smedt, Stefaan C; Raemdonck, Koen.
Afiliação
  • Bogaert B; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Bram.Bogaert@UGent.be.
  • Sauvage F; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Felix.Sauvage@UGent.be.
  • Guagliardo R; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Roberta.Guagliardo@UGent.be.
  • Muntean C; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Cristina.Muntean@UGent.be.
  • Nguyen VP; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA. Electronic address: vanphucn@med.umich.edu.
  • Pottie E; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Eline.Pottie@UGent.be.
  • Wels M; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Mike.Wels@UGent.be.
  • Minnaert AK; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: AnKatrienPaula.Minnaert@UGent.be.
  • De Rycke R; Ghent University Expertise Center for Transmission Electron Microscopy and VIB BioImaging Core, 9052 Ghent, Belgium. Electronic address: Riet.DeRycke@UGent.be.
  • Yang Q; Experimental Cardiology Laboratory, Regenerative Medicine Center Utrecht and Circulatory Health Laboratory, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, Utrecht, the Netherlands. Electronic address: q.yang@umcutrecht.nl.
  • Peer D; Laboratory of Precision NanoMedicine, Shmunis School of Biomedicine and Cancer Research, Tel-Aviv University, Ramat Aviv, Tel-Aviv 69978, Israel. Electronic address: peer@tauex.tau.ac.il.
  • Sanders N; Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium. Electronic address: Niek.Sanders@UGent.be.
  • Remaut K; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Katrien.Remaut@UGent.be.
  • Paulus YM; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA. Electronic address: ypaulus@med.umich.edu.
  • Stove C; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Christophe.Stove@UGent.be.
  • De Smedt SC; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Stefaan.Desmedt@UGent.be.
  • Raemdonck K; Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Koen.Raemdonck@UGent.be.
J Control Release ; 350: 256-270, 2022 10.
Article em En | MEDLINE | ID: mdl-35963467
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article