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Challenging diagnosis and successful treatment of localised Mycobacterium avium subsp. hominissuis glossitis in a dog on long-term immunomodulatory therapy.
Häußler, T C; Thom, N; Prenger-Berninghoff, E; Köhler, K; Barth, S A.
Afiliação
  • Häußler TC; Clinic for Small Animals, Surgical Department, Justus Liebig University, Giessen, Germany.
  • Thom N; Clinic for Small Animals, Department of Dermatology, Justus Liebig University, Giessen, Germany.
  • Prenger-Berninghoff E; Institute of Hygiene and Infectious Diseases of Animals, Justus Liebig University, Giessen, Germany.
  • Köhler K; Institute of Veterinary Pathology, Justus Liebig University, Giessen, Germany.
  • Barth SA; Friedrich-Loeffler-Institute/Federal Research Institute for Animal Health, Institute of Molecular Pathogenesis, Jena, Germany.
N Z Vet J ; 70(6): 340-348, 2022 Nov.
Article em En | MEDLINE | ID: mdl-35968551
CASE HISTORY: A 3-year-old, intact female mixed-breed dog, weighing 7 kg, was presented with generalised swelling of the tongue, leading to impaired deglutition and episodes of dyspnoea. From the age of 2 years, the dog had been under immunosuppressive therapy due to atopic dermatitis. CLINICAL FINDINGS AND TREATMENT: Multiple nodular lesions at the apex of the tongue were noted as well as mandibular and retropharyngeal lymph node enlargement. Serum biochemistry results showed inflammatory changes. The results of several biopsies taken over 7 months indicated persistent pyogranulomatous and necrotising glossitis despite ongoing antimicrobial treatment, first with amoxicillin/clavulanic acid and then pradofloxacin. No foreign material, acid-fast bacteria or fungal hyphae were detected throughout. The final diagnosis of Mycobacterium avium subsp. hominissuis (Mah) was reached after PCR and bacterial culture were carried out on the third biopsy sample. Therapy was initiated with rifampicin, clarithromycin and doxycycline, leading to complete remission of the lesions. DIAGNOSIS: Severe chronic pyogranulomatous and necrotising glossitis associated with infection by Mah. CLINICAL RELEVANCE: This report describes challenges in the diagnosis and therapy of a localised Mah infection in an iatrogenically immunocompromised dog. Successful treatment was only achieved with a specific combination of antibiotics administered long-term. ABBREVIATIONS: AF: Acid-fast; ALP: Alkaline phosphatase; CT: Computed tomography; MAC: Mycobacterium avium complex; Mah: Mycobacterium avium subsp. hominissuis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Glossite Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Glossite Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article