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Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.
Reinbold, Raphael; Hvinden, Ingvild C; Rabe, Patrick; Herold, Ryan A; Finch, Alina; Wood, James; Morgan, Melissa; Staudt, Maximillian; Clifton, Ian J; Armstrong, Fraser A; McCullagh, James S O; Redmond, Jo; Bardella, Chiara; Abboud, Martine I; Schofield, Christopher J.
Afiliação
  • Reinbold R; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.
  • Hvinden IC; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.
  • Rabe P; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.
  • Herold RA; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK.
  • Finch A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Wood J; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Morgan M; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Staudt M; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Clifton IJ; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Armstrong FA; Institute of Pharmaceutical Sciences, University of Freiburg, 79104, Freiburg, Germany.
  • McCullagh JSO; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.
  • Redmond J; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK.
  • Bardella C; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.
  • Abboud MI; GlaxoSmithKline, Gunnels Wood Rd, Stevenage, SG1 2NY, UK.
  • Schofield CJ; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Nat Commun ; 13(1): 4785, 2022 08 15.
Article em En | MEDLINE | ID: mdl-35970853
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Resistencia a Medicamentos Antineoplásicos / Isocitrato Desidrogenase Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Resistencia a Medicamentos Antineoplásicos / Isocitrato Desidrogenase Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article