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A GLP1 receptor agonist diabetes drug ameliorates neurodegeneration in a mouse model of infantile neurometabolic disease.
Poupon-Bejuit, L; Hughes, M P; Liu, W; Geard, A; Faour-Slika, N; Whaler, S; Massaro, G; Rahim, A A.
Afiliação
  • Poupon-Bejuit L; UCL School of Pharmacy, University College London, London, UK.
  • Hughes MP; UCL School of Pharmacy, University College London, London, UK.
  • Liu W; UCL School of Pharmacy, University College London, London, UK.
  • Geard A; UCL School of Pharmacy, University College London, London, UK.
  • Faour-Slika N; UCL School of Pharmacy, University College London, London, UK.
  • Whaler S; UCL School of Pharmacy, University College London, London, UK.
  • Massaro G; UCL School of Pharmacy, University College London, London, UK. giulia.massaro.13@ucl.ac.uk.
  • Rahim AA; UCL School of Pharmacy, University College London, London, UK. a.rahim@ucl.ac.uk.
Sci Rep ; 12(1): 13825, 2022 08 15.
Article em En | MEDLINE | ID: mdl-35970890
ABSTRACT
Infantile neuroaxonal dystrophy (INAD) is a rare paediatric neurodegenerative condition caused by mutations in the PLA2G6 gene, which is also the causative gene for PARK14-linked young adult-onset dystonia parkinsonism. INAD patients usually die within their first decade of life, and there are currently no effective treatments available. GLP1 receptor (GLP-1R) agonists are licensed for treating type 2 diabetes mellitus but have also demonstrated neuroprotective properties in a clinical trial for Parkinson's disease. Therefore, we evaluated the therapeutic efficacy of a new recently licensed GLP-1R agonist diabetes drug in a mouse model of INAD. Systemically administered high-dose semaglutide delivered weekly to juvenile INAD mice improved locomotor function and extended the lifespan. An investigation into the mechanisms underlying these therapeutic effects revealed that semaglutide significantly increased levels of key neuroprotective molecules while decreasing those involved in pro-neurodegenerative pathways. The expression of mediators in both the apoptotic and necroptotic pathways were also significantly reduced in semaglutide treated mice. A reduction of neuronal loss and neuroinflammation was observed. Finally, there was no obvious inflammatory response in wild-type mice associated with the repeated high doses of semaglutide used in this study.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofias Neuroaxonais / Transtornos Parkinsonianos / Diabetes Mellitus Tipo 2 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofias Neuroaxonais / Transtornos Parkinsonianos / Diabetes Mellitus Tipo 2 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article