Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris.
Chem Biodivers
; 19(10): e202200374, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-35975750
ABSTRACT
Two new depsidones, himantormiones A and B (1 and 2) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds (3-9). The structures of two new compounds (1 and 2) were determined by means of spectroscopic analyses, including 1D and 2D NMR and HR-MS. The isolated compounds were tested for antimicrobial and cytotoxic activities, where himantormione B (2) exhibited inhibitory effect against Staphylococcus aureus with the IC50 value of 7.01±0.85â
mM. Compound 2 also exhibited strong cytotoxic activity against HCT116 cells (colon cancer) with the EC50 value of 1.11±0.85â
µM, where that of the positive control, 5-fluouracil, was 9.4±1.90â
µM.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parmeliaceae
/
Líquens
/
Anti-Infecciosos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article