Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced G&#945;i3 and G&#945;oA Isoprotein Activation.

Fisher, Courtney L; Fallot, Lucas B; Wan, Tina C; Keyes, Robert F; Suresh, R Rama; Rothwell, Amy C; Gao, Zhan-Guo; McCorvy, John D; Smith, Brian C; Jacobson, Kenneth A; Auchampach, John A

Characterization of Dual-Acting A₃ Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gα_i3 and Gα_oA Isoprotein Activation.

Fisher, Courtney L; Fallot, Lucas B; Wan, Tina C; Keyes, Robert F; Suresh, R Rama; Rothwell, Amy C; Gao, Zhan-Guo; McCorvy, John D; Smith, Brian C; Jacobson, Kenneth A; Auchampach, John A.

Afiliação

Fisher CL; Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Fallot LB; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
Wan TC; Department of Biochemistry & Molecular Biology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, United States.
Keyes RF; Department of Chemistry & Life Science, United States Military Academy, 646 Swift Road, West Point, New York 10996, United States.
Suresh RR; Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Rothwell AC; Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Gao ZG; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
McCorvy JD; Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Smith BC; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
Jacobson KA; Department of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Auchampach JA; Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.

ACS Pharmacol Transl Sci ; 5(8): 625-641, 2022 Aug 12.

Article em En | MEDLINE | ID: mdl-35983277

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article