Substituent Orchestration in Dimethylquinoxaline Derivatives: A Tool for Fishing Out Appropriate CDK5 Inhibitors as Potential Therapeutics for Alzheimer's.

Jain, Arvind Kumar; Gupta, Arindam; Karthikeyan, C; Trivedi, Piyush; Konar, Anita Dutt

Jain, Arvind Kumar; Gupta, Arindam; Karthikeyan, C; Trivedi, Piyush; Konar, Anita Dutt.

Afiliação

Jain AK; School of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal, 462033, Madhya Pradesh, India.
Gupta A; Department of Chemistry, IISER Bhopal, Bhopal, 462066, Madhya Pradesh, India.
Karthikeyan C; Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak (MP), 484887, India.
Trivedi P; School of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal, 462033, Madhya Pradesh, India.
Konar AD; Center of Innovation & Translational Research, Bharati Vidyapeeth, Pune, 411038, Maharashtra, India.

Chem Biodivers ; 19(9): e202200116, 2022 Sep.

Article em En | MEDLINE | ID: mdl-35983935

Assuntos

Doença de Alzheimer; Animais; Doença de Alzheimer/tratamento farmacológico; Glicogênio Sintase Quinase 3 beta; Quinoxalinas/farmacologia

Palavras-chave

Density Functional Theory (DFT); alkoxy/hydroxy derivatives; selectivity towards CDK5

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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