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Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.
Liu, Haobai; Wang, Quan; Huang, Yue; Deng, Jinhui; Xie, Xi; Zhu, Jiaqi; Yuan, Yijun; He, Yue-Ming; Huang, Yi-You; Luo, Hai-Bin; He, Xixin.
Afiliação
  • Liu H; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
  • Wang Q; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, PR China.
  • Huang Y; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, PR China.
  • Deng J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
  • Xie X; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
  • Zhu J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
  • Yuan Y; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China; Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya, 572000, China.
  • He YM; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
  • Huang YY; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, PR China; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China; Song Li' Academician Workstation of Hainan University (School
  • Luo HB; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, PR China; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China; Song Li' Academician Workstation of Hainan University (School
  • He X; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China. Electronic address: mark07@gzucm.edu.cn.
Eur J Med Chem ; 242: 114631, 2022 Nov 15.
Article em En | MEDLINE | ID: mdl-35985255
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Inibidores da Fosfodiesterase 4 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Inibidores da Fosfodiesterase 4 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article