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NA1-115-7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes.
Daressy, Florian; Séguy, Line; Favre, Loëtitia; Corvaisier, Sophie; Apel, Cécile; Groo, Anne-Claire; Litaudon, Marc; Dumontet, Vincent; Malzert-Fréon, Aurélie; Desrat, Sandy; Roussi, Fanny; Robert, Aude; Wiels, Joëlle.
Afiliação
  • Daressy F; CNRS UMR9018, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France; Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Séguy L; Normandie Université, UniCaen, CERMN, F-14000 Caen, France.
  • Favre L; Inserm U955, Université Paris-Est Créteil, F-94009 Créteil, France; AP-HP, CHU Henri Mondor, Département de Pathologie, F-94009 Créteil, France.
  • Corvaisier S; Normandie Université, UniCaen, CERMN, F-14000 Caen, France.
  • Apel C; Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Groo AC; Normandie Université, UniCaen, CERMN, F-14000 Caen, France.
  • Litaudon M; Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Dumontet V; Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Malzert-Fréon A; Normandie Université, UniCaen, CERMN, F-14000 Caen, France.
  • Desrat S; Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Roussi F; Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Robert A; Inserm UMR1279, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France. Electronic address: aude.robert@gustaveroussy.fr.
  • Wiels J; CNRS UMR9018, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France. Electronic address: joelle.wiels@gustaveroussy.fr.
Biomed Pharmacother ; 154: 113546, 2022 Oct.
Article em En | MEDLINE | ID: mdl-35988426
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article