Klotho in diabetic kidney disease: more than dust in the Wnt.
Kidney Int
; 102(3): 469-471, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35988933
ABSTRACT
Activation of the Wnt/ß-catenin pathway represents a hallmark in the development of kidney fibrosis. Herein, Chen et al. report that Klotho-derived peptide 6, a peptide mimicking the function of the protein Klotho, directly binds to endogenous Wnt ligands and, thereby, serves as a small-molecule inhibitor of canonical Wnt/ß-catenin signaling. In diabetic kidney disease, Klotho-derived peptide 6 reduces glomerular injury and preserves kidney function, highlighting Klotho-derived peptide 6 as a novel therapeutic agent.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nefropatias Diabéticas
/
Beta Catenina
/
Via de Sinalização Wnt
/
Proteínas Klotho
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article