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Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status.
Lama, Rati; Xu, Chao; Galster, Samuel L; Querol-García, Javier; Portwood, Scott; Mavis, Cory K; Ruiz, Federico M; Martin, Diana; Wu, Jin; Giorgi, Marianna C; Bargonetti, Jill; Wang, Eunice S; Hernandez-Ilizaliturri, Francisco J; Koudelka, Gerald B; Chemler, Sherry R; Muñoz, Inés G; Wang, Xinjiang.
Afiliação
  • Lama R; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
  • Xu C; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
  • Galster SL; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, United States.
  • Querol-García J; Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Portwood S; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
  • Mavis CK; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
  • Ruiz FM; Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Martin D; Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Wu J; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
  • Giorgi MC; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
  • Bargonetti J; The Department of Biological Sciences, Hunter College, City University of New York, New York, NY, United States.
  • Wang ES; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
  • Hernandez-Ilizaliturri FJ; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
  • Koudelka GB; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States.
  • Chemler SR; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, United States.
  • Muñoz IG; Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Wang X; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Front Oncol ; 12: 933446, 2022.
Article em En | MEDLINE | ID: mdl-35992795
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article