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The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus.
Clauss, Nikki; Allen, Kelsey Brass; Billings, Katie D; Tolliver, Mikayla D M; Garza, Ray; Byrd-Craven, Jennifer; Campbell, Polly.
Afiliação
  • Clauss N; Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA.
  • Allen KB; College of Medicine, University of Oklahoma Health Science Center, 1100 N Lindsay Ave, Oklahoma City, OK 73104, USA.
  • Billings KD; Department of Science and Mathematics, Mississippi College, Box 4053, Clinton, MS 39058, USA.
  • Tolliver MDM; Department of Psychological Science, 216 Memorial Hall, University of Arkansas, Fayetteville, AR 72701, USA.
  • Garza R; Department of Psychology and Communication, Texas A&M International University, 5201 University Blvd, Laredo, TX 78041, USA.
  • Byrd-Craven J; Department of Psychology, Oklahoma State University, 116 Psychology Building, Stillwater, OK 74078, USA.
  • Campbell P; Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, 900 University Ave, Riverside, CA 92521, USA.
Int J Mol Sci ; 23(16)2022 Aug 17.
Article em En | MEDLINE | ID: mdl-36012509
The impact of early developmental experience on neurobiological pathways that may contribute to the association between diet and behavior have not yet been elucidated. The focus of the current study was to determine whether the impact of prenatal stress (PS) could be mitigated by a diet that stimulates the same neuroendocrine systems influenced by early stress, using a mouse model. Behavioral and genetic approaches were used to assess how a Western-pattern diet (WPD) interacts with PS and sex to impact the expression of anxiety-like behavior in an open-field arena, as well as the expression of the glucocorticoid receptor in the hippocampus, D1 dopamine receptors in the nucleus accumbens, and D2 dopamine receptors in the ventral tegmental area. Overall, the results demonstrated that a prenatal WPD mitigates the effects of maternal stress in dams and offspring. These results help to elucidate the relationship between pre- and post-natal nutrition, gene expression, and behaviors that lead to long-term health effects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Receptores de Glucocorticoides / Receptores de Dopamina D2 / Receptores de Dopamina D1 / Dieta Ocidental Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Receptores de Glucocorticoides / Receptores de Dopamina D2 / Receptores de Dopamina D1 / Dieta Ocidental Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article