Developing an atroposelective dynamic kinetic resolution of MRTX1719 by resolving incompatible chemical operations.
Chem Commun (Camb)
; 58(74): 10365-10367, 2022 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-36017676
ABSTRACT
A high-yielding protocol for atropisomeric resolution was developed by rectifying incompatibilities between crystallization and epimerization via continuous processing. Application toward synthesis of MRTX1719, a densely functionalized active pharmaceutical ingredient (API), improved yield from 37% to 87%. This protocol provides a complementary means to access rotamers which challenge current asymmetric methodologies, and greatly improves sustainability by decreasing the consumption of solvent and advanced synthetic intermediates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cristalização
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article