Engineering the methyltransferase through inactivation of the genK and genL leads to a significant increase of gentamicin C1a production in an industrial strain of Micromonospora echinospora 49-92S.

Xu, Feng; Zhang, Xinyu; Liu, Ling; Ke, Xiang; Wu, Jie; Guo, Yuanxin; Tian, Xiwei; Chu, Ju

Xu, Feng; Zhang, Xinyu; Liu, Ling; Ke, Xiang; Wu, Jie; Guo, Yuanxin; Tian, Xiwei; Chu, Ju.

Afiliação

Xu F; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Zhang X; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Liu L; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Ke X; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Wu J; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Guo Y; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Tian X; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China. xiweitian@ecust.edu.cn.
Chu J; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China. juchu@ecust.edu.cn.

Bioprocess Biosyst Eng ; 45(10): 1693-1703, 2022 Oct.

Article em En | MEDLINE | ID: mdl-36029348

Assuntos

Micromonospora; Fermentação; Gentamicinas/metabolismo; Gentamicinas/farmacologia; Metiltransferases/genética; Micromonospora/genética; Micromonospora/metabolismo

Palavras-chave

GenKgenL; Gentamicin C1a; Metabolic flux analysis; Methyltransferase; Micromonospora echinospora

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Micromonospora Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Micromonospora Idioma: En Ano de publicação: 2022 Tipo de documento: Article