Design and fabrication of new anticancer sensor for monitoring of daunorubicin using 1-methyl-3-octylimidazolinium chloride and tin oxide/nitrogen-doped graphene quantum dot nanocomposite electrochemical sensor.
Environ Res
; 215(Pt 1): 114114, 2022 12.
Article
em En
| MEDLINE
| ID: mdl-36030915
ABSTRACT
In this study, a novel tin oxide/nitrogen-doped graphene quantum dot nanocomposite (SnO2-NDGQD) and 1-methyl-3-octylimidazolinium chloride (1M3OICl) ionic liquid amplified carbon paste electrode (CPE) was fabricated as an efficient and fast-response sensor to determine daunorubicin, an anticancer drug. The electrochemical characteristics of daunorubicin at the surface of the 1M3OICl/SnO2-NDGQD/CPE was explored via various voltammetric methods. The high-resolution transmission electron microscope (HR-TEM) images were recorded to examine the morphological structure of the as-synthesized nanocomposites. The 1M3OICl/SnO2-NDGQD/CPE offered a wide linear concentration of 0.001-280.0 µM with a low detection limit of 0.40 nM at the optimized experimental conditions using square wave voltammetric (SWV) method. In a nutshell, the developed electrode illustrated outstanding selectivity in the presence of interfering agents and long-term stability. The1M3OICl/SnO2-NDGQD/CPE was used as new and powerful analytical tool for determination of daunorubicin in real samples with recovery range 98.75%-104.8%.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pontos Quânticos
/
Líquidos Iônicos
/
Nanocompostos
/
Grafite
/
Cloreto de Metila
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article