Stent-Based Gene Delivery for Coronary Disease.
Methods Mol Biol
; 2573: 217-233, 2022.
Article
em En
| MEDLINE
| ID: mdl-36040598
ABSTRACT
Percutaneous coronary interventions (PCI) are the mainstay for treatment of advanced coronary disease. A majority of PCI involve deployment of a stent in the affected vascular segment. This chapter introduces the concept of using stents as a platform for delivering gene therapies to the vasculature with the overarching aim of mitigating in-stent restenosis (ISR), late stent thrombosis (LST), and neoatherosclerosis (NA), a triad of delayed complications that reduce the overall success rate of PCI. The chapter provides a detailed methodology for coatless reversible attachment of adenoviral (Ad) and adeno-associated viral (AAV) vectors to the metal stent struts along with representative in vitro and in vivo results.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Reestenose Coronária
/
Intervenção Coronária Percutânea
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article