[Role of the gut microbiome in the pathogenesis and treatment of inflammatory bowel diseases]. / Das Darmmikrobiom in der Pathogenese und Therapie chronisch-entzündlicher Darmerkrankungen.
Inn Med (Heidelb)
; 63(10): 1022-1027, 2022 Oct.
Article
em De
| MEDLINE
| ID: mdl-36044059
ABSTRACT
Inflammatory bowel diseases (IBD) are systemic diseases that mainly manifest in the gastrointestinal tract. Due to chronically impaired intestinal homeostasis, they often require permanent and in some cases systemic therapy. The exact causes of IBD are largely unknown. It is postulated that these complex diseases arise in genetically susceptible individuals through a misdirected immune response, promoted by barrier defects, environmental toxins, and the gut microbiome. In this regard, the importance of the microbiome and its pathogenic changes (dysbiosis) in the pathogenesis of IBD is increasingly coming into focus. This review article presents the current state of research on the role of the microbiome in the development of IBD. Therapeutic approaches aimed at correcting intestinal dysbiosis are also discussed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Microbioma Gastrointestinal
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
De
Ano de publicação:
2022
Tipo de documento:
Article