Most cancers carry a substantial deleterious load due to Hill-Robertson interference.

Tilk, Susanne; Tkachenko, Svyatoslav; Curtis, Christina; Petrov, Dmitri A; McFarland, Christopher D

Tilk, Susanne; Tkachenko, Svyatoslav; Curtis, Christina; Petrov, Dmitri A; McFarland, Christopher D.

Afiliação

Tilk S; Department of Biology, Stanford University, Stanford, United States.
Tkachenko S; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.
Curtis C; Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, United States.
Petrov DA; Department of Genetics, Stanford University School of Medicine, Stanford, United States.
McFarland CD; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, United States.

Elife ; 112022 09 01.

Article em En | MEDLINE | ID: mdl-36047771

Assuntos

Neoplasias; Seleção Genética; Evolução Molecular; Variação Genética; Humanos; Modelos Genéticos; Mutação; Neoplasias/genética; Recombinação Genética

Palavras-chave

Hill-Robertson interference; cancer evolution; evolutionary biology; genetics; genomics; human; mutation load

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seleção Genética / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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