A gut reaction: Microbiome-driven glycemic effects of non-nutritive sweeteners.

Non-nutritive sweeteners are increasingly consumed to satisfy cravings for sweet taste without the associated calories. Paradoxically, non-nutritive sweeteners have been linked to metabolic risks, but the underlying mechanisms are not understood. In this issue of Cell, Suez and colleagues pinpoint changes in the gut microbiome as a mechanism for non-nutritive sweetener-induced glycemic impairments in healthy adults.