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X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.
Lee, Jaeyong; Kenward, Calem; Worrall, Liam J; Vuckovic, Marija; Gentile, Francesco; Ton, Anh-Tien; Ng, Myles; Cherkasov, Artem; Strynadka, Natalie C J; Paetzel, Mark.
Afiliação
  • Lee J; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
  • Kenward C; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
  • Worrall LJ; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
  • Vuckovic M; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
  • Gentile F; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
  • Ton AT; Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, V6H 3Z6, Canada.
  • Ng M; Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, V6H 3Z6, Canada.
  • Cherkasov A; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
  • Strynadka NCJ; Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, V6H 3Z6, Canada.
  • Paetzel M; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. ncjs@mail.ubc.ca.
Nat Commun ; 13(1): 5196, 2022 09 03.
Article em En | MEDLINE | ID: mdl-36057636
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliproteínas / Proteases 3C de Coronavírus / SARS-CoV-2 / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliproteínas / Proteases 3C de Coronavírus / SARS-CoV-2 / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article