Identification of genetic mechanisms for tissue-specific genetic effects based on CRISPR screens.

Dvir, Elad; Shohat, Shahar; Flint, Jonathan; Shifman, Sagiv

Dvir, Elad; Shohat, Shahar; Flint, Jonathan; Shifman, Sagiv.

Afiliação

Dvir E; Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Shohat S; Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Flint J; Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Shifman S; Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Genetics ; 222(3)2022 11 01.

Article em En | MEDLINE | ID: mdl-36063051

Assuntos

Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas; Neoplasias; Humanos; Sistemas CRISPR-Cas; Linhagem Celular; Neoplasias/genética; Amplificação de Genes

Palavras-chave

CRISPR screens; essential genes; genes intolerant to mutations; paralogs; tissue specificity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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