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A smartphone-assisted hybrid sensor for simultaneous potentiometric and distance-based detection of electrolytes.
Phoonsawat, Kamonchanok; Agir, Ismail; Dungchai, Wijitar; Ozer, Tugba; Henry, Charles S.
Afiliação
  • Phoonsawat K; Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Prachautid Road, Thungkru, Bangkok, 10140, Thailand; Department of Chemistry, Colorado State University, Fort Collins, CO, 80523, Un
  • Agir I; Department of Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Istanbul, Turkey.
  • Dungchai W; Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Prachautid Road, Thungkru, Bangkok, 10140, Thailand.
  • Ozer T; Department of Chemistry, Colorado State University, Fort Collins, CO, 80523, United States; Department of Bioengineering, Faculty of Chemical-Metallurgical Engineering, Yildiz Technical University, 34220, Istanbul, Turkey. Electronic address: tozer@yildiz.edu.tr.
  • Henry CS; Department of Chemistry, Colorado State University, Fort Collins, CO, 80523, United States; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, 80523, United States; Metallurgy and Materials Science Research Institute, Chulalongkorn University, Bangkok, Thailand. Electroni
Anal Chim Acta ; 1226: 340245, 2022 Sep 15.
Article em En | MEDLINE | ID: mdl-36068053
ABSTRACT
At home electrolyte analysis is of growing interest due to the importance for early diagnosis for various diseases. This work presents the first device that integrates a potentiometric ion-selective electrode (ISE) with distance-based colorimetric detection for the simultaneous analysis of K+ and Cl- ions at the point of care (POC). This hybrid sensing device was designed in a two-dimensional configuration using a plastic transparency sheet containing a stencil printed K+-ISE and a paper substrate for distance-based colorimetric detection of Cl-. K+ quantification was performed using a low-cost (<$25) lab-made Wi-Fi supported potentiometer with a custom smartphone application while Cl- ions were quantified with an instrument-free distance-based paper analytical device (dPAD). The total analysis time is 5 min once the sample is added. The K+-ISE showed a sensitivity of 55.89 ± 2.52 mV/decade from 0.1 to 100 mM with a limit of detection (LOD) of 0.01 mM. The linear working range for Cl- detection was 0.5-50 mM whereas the LOD was 0.16 ± 0.05 mM. The proof-of-concept application of the sensing hybrid device was demonstrated in human urine and artificial sweat samples containing K+ and Cl- ions at physiologically relevant ranges. The recoveries were found to be 88-108% for K+ and 90-104% for Cl-, showing the potential use of the proposed device for low-cost routine analysis of biological samples at POC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eletrodos Seletivos de Íons / Smartphone Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eletrodos Seletivos de Íons / Smartphone Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article