Protective effects and DNA repair induction of a coumarin-chalcone hybrid against genotoxicity induced by mutagens.

Véras, Jefferson Hollanda; Do Vale, Camila Regina; Luiz Cardoso Bailão, Elisa Flávia; Dos Anjos, Murilo Machado; Cardoso, Clever Gomes; de Oliveira, Matheus Gabriel; de Paula, José Realino; de Oliveira, Guilherme Roberto; Silva, Carolina Ribeiro E; Chen-Chen, Lee

Véras, Jefferson Hollanda; Do Vale, Camila Regina; Luiz Cardoso Bailão, Elisa Flávia; Dos Anjos, Murilo Machado; Cardoso, Clever Gomes; de Oliveira, Matheus Gabriel; de Paula, José Realino; de Oliveira, Guilherme Roberto; Silva, Carolina Ribeiro E; Chen-Chen, Lee.

Afiliação

Véras JH; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
Do Vale CR; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
Luiz Cardoso Bailão EF; Laboratory of Biotechnology, Henrique Santillo Campus, State University of Goiás, Anápolis, Brazil.
Dos Anjos MM; Chemistry Institute, Federal University of Goiás, Goiânia, Brazil.
Cardoso CG; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
de Oliveira MG; School of Pharmacy, Federal University of Goiás, Goiânia, Brazil.
de Paula JR; School of Pharmacy, Federal University of Goiás, Goiânia, Brazil.
de Oliveira GR; Chemistry Institute, Federal University of Goiás, Goiânia, Brazil.
Silva CRE; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
Chen-Chen L; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.

J Toxicol Environ Health A ; 85(22): 937-951, 2022 Nov 17.

Article em En | MEDLINE | ID: mdl-36068785

Assuntos

Chalcona; Chalconas; Chalconas/farmacologia; Ensaio Cometa/métodos; Cumarínicos/farmacologia; Ciclofosfamida; Dano ao DNA; Reparo do DNA; Glutationa Redutase; Testes para Micronúcleos; Simulação de Acoplamento Molecular; Mutagênicos/toxicidade

Palavras-chave

Ames test; antigenotoxicity; comet assay; micronucleus test; molecular docking

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chalcona / Chalconas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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