Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate.

Cavalli, Marco; Eriksson, Niclas; Sundbaum, Johanna Karlsson; Wallenberg, Matilda; Kohnke, Hugo; Baecklund, Eva; Hallberg, Pär; Wadelius, Mia

Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate.

Cavalli, Marco; Eriksson, Niclas; Sundbaum, Johanna Karlsson; Wallenberg, Matilda; Kohnke, Hugo; Baecklund, Eva; Hallberg, Pär; Wadelius, Mia.

Afiliação

Cavalli M; Department of Medical Sciences, Clinical Pharmacogenomics & Science for Life Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden.
Eriksson N; Department of Immunology, Genetics & Pathology, & Science for Life Laboratory, Uppsala University, SE-751 22, Uppsala, Sweden.
Sundbaum JK; Department of Medical Sciences, Clinical Pharmacogenomics & Science for Life Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden.
Wallenberg M; Uppsala Clinical Research Center, SE-751 85, Uppsala, Sweden.
Kohnke H; Department of Medical Sciences, Rheumatology, Uppsala University, SE-751 85, Uppsala, Sweden.
Baecklund E; Department of Health Sciences, Luleå University of Technology, SE-971 87, Luleå, Sweden.
Hallberg P; Department of Medical Sciences, Clinical Pharmacogenomics & Science for Life Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden.
Wadelius M; Svensk Dos AB, Box 2, SE-751 03, Uppsala, Sweden.

Pharmacogenomics ; 23(15): 813-820, 2022 10.

Article em En | MEDLINE | ID: mdl-36070248

Assuntos

Antirreumáticos; Artrite Reumatoide; Humanos; Masculino; Metotrexato/efeitos adversos; Estudo de Associação Genômica Ampla; Alanina Transaminase; Artrite Reumatoide/tratamento farmacológico; Artrite Reumatoide/genética; Fígado; Antirreumáticos/efeitos adversos

Palavras-chave

adverse reactions; drug-related side effects; genome-wide association study; hepatotoxicity; methotrexate; pharmacogenetics; rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Antirreumáticos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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