The spatial scale of somatostatin subnetworks increases from sensory to association cortex.
Cell Rep
; 40(10): 111319, 2022 09 06.
Article
em En
| MEDLINE
| ID: mdl-36070697
ABSTRACT
Incoming signals interact with rich, ongoing population activity dynamics in cortical circuits. These intrinsic dynamics are the consequence of interactions among local excitatory and inhibitory neurons and affect inter-region communication and information coding. It is unclear whether specializations in the patterns of interactions among excitatory and inhibitory neurons underlie systematic differences in activity dynamics across the cortex. Here, in mice, we compare the functional interactions among somatostatin (SOM)-expressing inhibitory interneurons and the rest of the neural population in auditory cortex (AC), a sensory region of the cortex, and posterior parietal cortex (PPC), an association region. The spatial structure of shared variability among SOM and non-SOM neurons differs across regions correlations decay rapidly with distance in AC but not in PPC. However, in both regions, activity of SOM neurons is more highly correlated than non-SOM neurons' activity. Our results imply both generalization and specialization in the functional structure of inhibitory subnetworks across the cortex.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Auditivo
/
Somatostatina
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article