Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4.
J Antibiot (Tokyo)
; 75(10): 535-541, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-36071214
ABSTRACT
In the course of our screening program for new anti-methicillin-resistant Staphylococcus aureus antibiotics, four novel antibiotics, termed wychimicins A-D, were isolated from the culture broth of the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicins are spirotetronates possessing a macrocyclic 13-membered ring containing trans-decalin and ß-D-xylo-hexopyranose moieties connected to C-17 by an O-glycosidic linkage according to MS, NMR and X-ray analyses. In X-ray crystal structure analysis, the Flack constant was 0.10 (11). The stereochemistry of the spirocarbon C-25 was R. Wychimicins had a minimum inhibitory concentration of 0.125-2 µg ml-1 against methicillin-resistant Staphylococcus aureus.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Actinomycetales
/
Actinobacteria
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Staphylococcus aureus Resistente à Meticilina
/
Policetídeos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article