Function and structure of bradykinin receptor 2 for drug discovery.
Acta Pharmacol Sin
; 44(3): 489-498, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36075965
Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that regulates the cardiovascular system as a vasodepressor. Dysfunction of B2R is also closely related to cancers and hereditary angioedema (HAE). Although several B2R agonists and antagonists have been developed, icatibant is the only B2R antagonist clinically used for treating HAE. The recently determined structures of B2R have provided molecular insights into the functions and regulation of B2R, which shed light on structure-based drug design for the treatment of B2R-related diseases. In this review, we summarize the structure and function of B2R in relation to drug discovery and discuss future research directions to elucidate the remaining unknown functions of B2R dimerization.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptor B2 da Bradicinina
/
Antagonistas de Receptor B2 da Bradicinina
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article