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Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone.
Grigalunas, Michael; Patil, Sohan; Krzyzanowski, Adrian; Pahl, Axel; Flegel, Jana; Schölermann, Beate; Xie, Jianing; Sievers, Sonja; Ziegler, Slava; Waldmann, Herbert.
Afiliação
  • Grigalunas M; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, 44227, Germany.
  • Patil S; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, 44227, Germany.
  • Krzyzanowski A; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, 44227, Germany.
  • Pahl A; Technical University Dortmund, Faculty of Chemistry, Chemical Biology, Dortmund, 44227, Germany.
  • Flegel J; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, 44227, Germany.
  • Schölermann B; Compound Management and Screening Center, Dortmund, 44227, Germany.
  • Xie J; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, 44227, Germany.
  • Sievers S; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, 44227, Germany.
  • Ziegler S; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, 44227, Germany.
  • Waldmann H; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, 44227, Germany.
Chemistry ; 28(67): e202202164, 2022 Dec 01.
Article em En | MEDLINE | ID: mdl-36083197
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Policetídeos / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Policetídeos / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article