Investigating the uncertainty of prediction accuracy for the application of physiologically based pharmacokinetic models to animal-free risk assessment of cosmetic ingredients.

Terasaka, Shimpei; Hayashi, Akane; Nukada, Yuko; Yamane, Masayuki

Terasaka, Shimpei; Hayashi, Akane; Nukada, Yuko; Yamane, Masayuki.

Afiliação

Terasaka S; Kao Corporation, Safety Science Research, 2-1-3, Bunka, Sumida-Ku, Tokyo, 131-8501, Japan. Electronic address: terasaka.shinpei@kao.com.
Hayashi A; Kao Corporation, Safety Science Research, 2-1-3, Bunka, Sumida-Ku, Tokyo, 131-8501, Japan.
Nukada Y; Kao Corporation, Safety Science Research, 2-1-3, Bunka, Sumida-Ku, Tokyo, 131-8501, Japan.
Yamane M; Kao Corporation, Safety Science Research, 2-1-3, Bunka, Sumida-Ku, Tokyo, 131-8501, Japan.

Regul Toxicol Pharmacol ; 135: 105262, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36103952

Assuntos

Cosméticos; Reprodutibilidade dos Testes; Medição de Risco; Incerteza; Cosméticos/farmacocinética

Palavras-chave

Animal-free risk assessment; Modeling uncertainty factor; New approach methodologies; Physiologically based pharmacokinetic model; Prediction accuracy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cosméticos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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