Comparison of pre-formalin fixation and postfixation temporal artery biopsy lengths.
Can J Ophthalmol
; 58(6): 539-542, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-36108789
ABSTRACT
OBJECTIVE:
To evaluate the difference in temporal artery biopsy length before and after formalin fixation and identify any correlations with pathologic diagnosis.DESIGN:
Prospective case series.PARTICIPANTS:
Patients undergoing temporal artery biopsy between June 2020 and October 2021.METHODS:
The pre- and postfixation biopsy lengths were compared. The primary outcome was the difference in temporal artery length as measured before fixation by the surgeon versus the postfixation measurement by the pathologist.RESULTS:
Forty-seven consecutive biopsies in 46 patients were included. One patient had a repeat biopsy. Mean age was 75.3 ± 8.4 years (range, 49-94 years); 74% of patients (34 of 46 patients) were female. Mean prefixation biopsy length was 2.36 ± 0.58 cm (range, 1.1-4.5 cm). Mean postfixation biopsy length was 2.09 ± 0.59 cm (range, 0.6-3.8 cm). Mean difference (postfixation shrinkage) was 0.27 ± 0.24 cm (pâ¯=â¯0.0298), and 36% of biopsies (17 of 47 biopsies) were positive. There was no significant difference in prefixation temporal artery biopsy length (pâ¯=â¯0.38) or postfixation shrinkage (pâ¯=â¯0.24) between positive and negative biopsies. In a univariate analysis, elevated erythrocyte sedimentation rate was 31.3 mm/h (range, 4-88 mm/h) in negative biopsies versus 54.5 mm/h (range, 29-98 mm/h) in positive biopsies (pâ¯=â¯0.01), C-reactive protein was 17.4 mg/L (range, 0.2-145 mg/L) in negative biopsies versus 78.56 mg/L (range, 5-244.4 mg/L) in positive biopsies (pâ¯=â¯0.003), and platelets were 254.9â¯×â¯109/L (range, 134-570â¯×â¯109/L) in negative biopsies versus 393.8â¯×â¯109/L (range, 210-593â¯×â¯109/L) in positive biopsies (p < 0.001), all associated with a positive pathologic diagnosis.CONCLUSIONS:
The average temporal artery biopsy was approximately 0.27 cm shorter on pathologic reports compared with before fixation measurements. Surgeons should account for this shrinkage with a buffer of at least 0.3 cm, aiming for excision of at least 2.3 cm, if they desire a postfixation size of 2 cm.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arterite de Células Gigantes
/
Cirurgiões
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article