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Late hepatitis C virus diagnosis among patients with newly diagnosed hepatocellular carcinoma: a case-control study.
Chang, Shen-Shong; Hu, Hsiao-Yun; Chen, Yu-Chin; Yen, Yung-Feng; Huang, Nicole.
Afiliação
  • Chang SS; Division of Gastroenterology, Taipei City Hospital Yang-Ming Branch, Taipei City, Taiwan.
  • Hu HY; Department of Internal Medicine, Taipei City Hospital Yang-Ming Branch, Taipei City, Taiwan.
  • Chen YC; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
  • Yen YF; Department of Public Health, Institute of Public Health, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
  • Huang N; Department of Public Health, Institute of Public Health, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
BMC Gastroenterol ; 22(1): 425, 2022 Sep 17.
Article em En | MEDLINE | ID: mdl-36115934
BACKGROUND: New direct-acting antiviral therapies have revolutionized hepatitis C virus (HCV) infection therapy. Nonetheless, once liver cirrhosis is established, the risk of hepatocellular carcinoma (HCC) still exists despite virus eradication. Late HCV diagnosis hinders timely access to HCV treatment. Thus, we determined trends and risk factors associated with late HCV among patients with a diagnosis of HCC in Taiwan. METHODS: We conducted a population-based unmatched case-control study. 2008-2018 Claims data were derived from the Taiwan National Health Insurance Research Database. Individuals with an initial occurrence of liver cancer between 2012 and 2018 were included. The late HCV group were referred as individuals who were diagnosed with HCC within 3 years after HCV diagnosis. The control group were referred as individuals who were diagnosed more than 3 years after the index date. We used multivariable logistic models to explore individual- and provider-level risk factors associated with a late HCV diagnosis. RESULTS: A decreasing trend was observed in the prevalence of late HCV-related HCC diagnosis between 2012 and 2018 in Taiwan. On an individual level, male, elderly patients, patients with diabetes mellitus (DM), and patients with alcohol-related disease had significantly higher risks of late HCV-related HCC diagnosis. On a provider level, patients who were mainly cared for by male physicians, internists and family medicine physicians had a significantly lower risk of late diagnosis. CONCLUSIONS: Elderly and patients who have DM and alcohol related disease should receive early HCV screening. In addition to comorbidities, physician factors also matter. HCV screening strategies shall take these higher risk patients and physician factors into consideration to avoid missing opportunities for early intervention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Carcinoma Hepatocelular / Hepatite C Crônica / Diabetes Mellitus / Neoplasias Hepáticas Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Carcinoma Hepatocelular / Hepatite C Crônica / Diabetes Mellitus / Neoplasias Hepáticas Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article