Based on molecular structures: Amyloid-ß generation, clearance, toxicity and therapeutic strategies.
Front Mol Neurosci
; 15: 927530, 2022.
Article
em En
| MEDLINE
| ID: mdl-36117918
ABSTRACT
Amyloid-ß (Aß) has long been considered as one of the most important pathogenic factors in Alzheimer's disease (AD), but the specific pathogenic mechanism of Aß is still not completely understood. In recent years, the development of structural biology technology has led to new understandings about Aß molecular structures, Aß generation and clearance from the brain and peripheral tissues, and its pathological toxicity. The purpose of the review is to discuss Aß metabolism and toxicity, and the therapeutic strategy of AD based on the latest progress in molecular structures of Aß. The Aß structure at the atomic level has been analyzed, which provides a new and refined perspective to comprehend the role of Aß in AD and to formulate therapeutic strategies of AD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article