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ROS-Responsive Glycopolymeric Nanoparticles for Enhanced Drug Delivery to Macrophages.
Shofolawe-Bakare, Oluwaseyi T; de Mel, Judith U; Mishra, Sushil K; Hossain, Mehjabeen; Hamadani, Christine M; Pride, Mercedes C; Dasanayake, Gaya S; Monroe, Wake; Roth, Eric W; Tanner, Eden E L; Doerksen, Robert J; Smith, Adam E; Werfel, Thomas A.
Afiliação
  • Shofolawe-Bakare OT; Department of Chemical Engineering, University of Mississippi, University, MS, 38677, USA.
  • de Mel JU; Department of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
  • Mishra SK; Department of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
  • Hossain M; Department of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
  • Hamadani CM; Department of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
  • Pride MC; Department of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
  • Dasanayake GS; Department of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
  • Monroe W; Department of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
  • Roth EW; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, 60208, USA.
  • Tanner EEL; Department of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
  • Doerksen RJ; Department of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
  • Smith AE; Department of Chemical Engineering, University of Mississippi, University, MS, 38677, USA.
  • Werfel TA; Department of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Macromol Biosci ; 22(12): e2200281, 2022 12.
Article em En | MEDLINE | ID: mdl-36125638
ABSTRACT
Macrophages play a diverse, key role in many pathologies, including inflammatory diseases, cardiovascular diseases, and cancer. However, many therapeutic strategies targeting macrophages suffer from systemic off-target toxicity resulting in notoriously narrow therapeutic windows. To address this shortcoming, the development of poly(propylene sulfide)-b-poly(methacrylamidoglucopyranose) [PPS-b-PMAG] diblock copolymer-based nanoparticles (PMAG NPs) capable of targeting macrophages and releasing drug in the presence of reactive oxygen species (ROS) is reported. PMAG NPs have desirable physicochemical properties for systemic drug delivery, including slightly negative surface charge, ≈100 nm diameter, and hemo-compatibility. Additionally, due to the presence of PPS in the NP core, PMAG NPs release drug cargo preferentially in the presence of ROS. Importantly, PMAG NPs display high cytocompatibility and are taken up by macrophages in cell culture at a rate ≈18-fold higher than PEGMA NPs-NPs composed of PPS-b-poly(oligoethylene glycol methacrylate). Computational studies indicate that PMAG NPs likely bind with glucose transporters such as GLUT 1/3 on the macrophage cell surface to facilitate high levels of internalization. Collectively, this study introduces glycopolymeric NPs that are uniquely capable of both receptor-ligand targeting to macrophages and ROS-dependent drug release and that can be useful in many immunotherapeutic settings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Nanopartículas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Nanopartículas Idioma: En Ano de publicação: 2022 Tipo de documento: Article