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The Effects of Short-Term PM2.5 Exposure on Pulmonary Function among Children with Asthma-A Panel Study in Shanghai, China.
Zhou, Ji; Lei, Ruoyi; Xu, Jianming; Peng, Li; Ye, Xiaofang; Yang, Dandan; Yang, Sixu; Yin, Yong; Zhang, Renhe.
Afiliação
  • Zhou J; Department of Atmospheric and Oceanic Sciences & Institute of Atmospheric Sciences, Fudan University, Shanghai 200437, China.
  • Lei R; Shanghai Typhoon Institute, China Meteorological Administration (CMA), Shanghai 200030, China.
  • Xu J; Shanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological Bureau, Shanghai 200030, China.
  • Peng L; Institute of Occupational Health and Environmental Health, School of Public Health, Lanzhou University, Lanzhou 730000, China.
  • Ye X; Shanghai Typhoon Institute, China Meteorological Administration (CMA), Shanghai 200030, China.
  • Yang D; Shanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological Bureau, Shanghai 200030, China.
  • Yang S; Shanghai Typhoon Institute, China Meteorological Administration (CMA), Shanghai 200030, China.
  • Yin Y; Shanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological Bureau, Shanghai 200030, China.
  • Zhang R; Shanghai Typhoon Institute, China Meteorological Administration (CMA), Shanghai 200030, China.
Article em En | MEDLINE | ID: mdl-36141658
ABSTRACT
Fine particulate matter (PM2.5) has been reported to be an important risk factor for asthma. This study was designed to evaluate the relationship between PM2.5 and lung function among children with asthma in Shanghai, China. From 2016 to 2019, a total of 70 Chinese children aged 4 to 14 in Shanghai were recruited for this panel study. The questionnaire was used to collect baseline information, and the lung function covering forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and peak expiratory flow (PEF) were carried out for each child more than twice during follow-up. Meanwhile, the simultaneous daily air atmospheric pollutants and meteorological data were collected. The linear mixed effect (LME) model was used to assess the relationship between air pollutants and lung function. A significantly negative association was found between PM2.5 and lung function in children with asthma. In the single-pollutant model, the largest effects of PM2.5 on lung function were found for lag 0-2, with FVC and FEV1 decreasing by 0.91% [95% confidence interval (CI) -1.75, -0.07] and 1.05% (95% CI -2.09, 0.00), respectively, for each 10 µg/m3 increase in PM2.5. In the multi-pollution model (adjusted PM2.5 + SO2 + O3), the maximum effects of PM2.5 on FVC and FEV1 also appeared for lag 0-2, with FVC and FEV1 decreasing by 1.57% (95% CI -2.69, -0.44) and 1.67% (95% CI -3.05, -0.26), respectively, for each 10 µg/m3 increase in PM2.5. In the subgroup analysis, boys, preschoolers (<6 years old) and hot seasons (May to September) were more sensitive to changes. Our findings may contribute to a better understanding of the short-term exposure effects of PM2.5 on lung function in children with asthma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Poluentes Atmosféricos / Poluição do Ar Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Poluentes Atmosféricos / Poluição do Ar Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article