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Correlation between Olive Oil Intake and Gut Microbiota in Colorectal Cancer Prevention.
Memmola, Raffaella; Petrillo, Angelica; Di Lorenzo, Sara; Altuna, Sara C; Habeeb, Baker Shalal; Soggiu, Alessio; Bonizzi, Luigi; Garrone, Ornella; Ghidini, Michele.
Afiliação
  • Memmola R; Department of Biochemical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
  • Petrillo A; Medical Oncology Unit, Ospedale del Mare, 80147 Naples, Italy.
  • Di Lorenzo S; Medical Oncology Unit, Ospedale del Mare, 80147 Naples, Italy.
  • Altuna SC; School of Medicine, University of Study of Campania "L. Vanvitelli", 80131 Naples, Italy.
  • Habeeb BS; Medical Oncology, Oncomedica C.A., Caracas 1060, Venezuela.
  • Soggiu A; Oncology Department, Shaqlawa Teaching Hospital, Shaqlawa City 44005, Iraq.
  • Bonizzi L; Department of Biochemical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
  • Garrone O; Department of Biochemical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
  • Ghidini M; Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20131 Milan, Italy.
Nutrients ; 14(18)2022 Sep 10.
Article em En | MEDLINE | ID: mdl-36145125
Extra virgin olive oil (EVOO) is a mainstay of the Mediterranean diet with its excellent balance of fats and antioxidant bioactive compounds. Both the phenolic and lipid fractions of EVOO contain a variety of antioxidant and anticancer substances which might protect from the development of colorectal cancer (CRC). The function of the intestinal microbiome is essential for the integrity of the intestinal epithelium, being protective against pathogens and maintaining immunity. Indeed, dysbiosis of the microbiota alters the physiological functions of the organ, leading to the onset of different diseases including CRC. It is known that some factors, including diet, could deeply influence and modulate the colon microenvironment. Although coming from animal models, there is increasing evidence that a diet rich in EVOO is linked to a significant reduction in the diversity of gut microbiome (GM), causing a switch from predominant bacteria to a more protective group of bacteria. The potential beneficial effect of the EVOO compounds in the carcinogenesis of CRC is only partially known and further trials are needed in order to clarify this issue. With this narrative review, we aim at discussing the available evidence on the effect of olive oil consumption on GM in the prevention of CRC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Dieta Mediterrânea / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Dieta Mediterrânea / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article