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Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.
Huh, Carey Y L; Leinonen, Henri; Nakayama, Taylor; Tomasello, Julia R; Zhang, Jianye; Zeitoun, Jack; Peach, John P; Halabi, Maximilian; Kiser, Jianying Z; Palczewski, Krzysztof; Kiser, Philip D; Gandhi, Sunil P.
Afiliação
  • Huh CYL; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
  • Leinonen H; Gavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio 70211, Finland.
  • Nakayama T; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
  • Tomasello JR; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
  • Zhang J; Gavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA.
  • Zeitoun J; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
  • Peach JP; Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Halabi M; Gavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA; Department of Physiology & Biophysics, University of California, Irvine, Irvine, CA 92697, USA.
  • Kiser JZ; Gavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA.
  • Palczewski K; Gavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA; Department of Physiology & Biophysics, University of California, Irvine, Irvine, CA 92697, USA; Department of Chemistry, University of Cali
  • Kiser PD; Gavin Herbert Eye Institute, Department of Ophthalmology, Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697, USA; Department of Physiology & Biophysics, University of California, Irvine, Irvine, CA 92697, USA; Research Service, VA Long Beach Healthcare
  • Gandhi SP; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: spgandhi@uci.edu.
Curr Biol ; 32(20): 4538-4546.e5, 2022 10 24.
Article em En | MEDLINE | ID: mdl-36152631
ABSTRACT
Despite the recent emergence of multiple cellular and molecular strategies to restore vision in retinal disorders, it remains unclear to what extent central visual circuits can recover when retinal defects are corrected in adulthood. We addressed this question in an Lrat-/- mouse model of Leber congenital amaurosis (LCA) in which retinal light sensitivity and optomotor responses are partially restored by 9-cis-retinyl acetate administration in adulthood. Following treatment, two-photon calcium imaging revealed increases in the number and response amplitude of visually responsive neurons in the primary visual cortex (V1). In particular, retinoid treatment enhanced responses from the ipsilateral eye, restoring the normal balance of eye-specific responses in V1. Additionally, the treatment rescued the modulation of cortical responses by arousal. These findings illustrate the significant plasticity of the adult central visual system and underscore the therapeutic potential of retinoid administration for adults with retinal diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Degeneração Retiniana Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Degeneração Retiniana Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article