The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.

Valada, Pedro; Hinz, Sonja; Vielmuth, Christin; Lopes, Cátia R; Cunha, Rodrigo A; Müller, Christa E; Lopes, João Pedro

Valada, Pedro; Hinz, Sonja; Vielmuth, Christin; Lopes, Cátia R; Cunha, Rodrigo A; Müller, Christa E; Lopes, João Pedro.

Afiliação

Valada P; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.
Hinz S; Pharmaceutical & Medicinal Chemistry, University of Bonn, 53121, Bonn, Germany.
Vielmuth C; Pharmaceutical & Medicinal Chemistry, University of Bonn, 53121, Bonn, Germany.
Lopes CR; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.
Cunha RA; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal. cunharod@gmail.com.
Müller CE; Faculty of Medicine, University of Coimbra, Coimbra, Portugal. cunharod@gmail.com.
Lopes JP; Pharmaceutical & Medicinal Chemistry, University of Bonn, 53121, Bonn, Germany.

Purinergic Signal ; 19(2): 451-461, 2023 06.

Article em En | MEDLINE | ID: mdl-36156760

Assuntos

Adenosina; Nucleosídeos; Ratos; Humanos; Animais; Adenosina/metabolismo; Nucleosídeos/metabolismo; Receptor A1 de Adenosina/metabolismo; Transmissão Sináptica/fisiologia; Antagonistas de Receptores Purinérgicos P1/farmacologia; Inosina/farmacologia; Hipocampo/metabolismo

Palavras-chave

A1 receptor; A2A receptor; Adenosine; Hippocampus; Inosine; Synaptic plasticity; Synaptic transmission

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenosina / Nucleosídeos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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